Monitor Closely (one)mitotane decreases amounts of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Mitotane is a powerful inducer of cytochrome P-4503A4; check when coadministered with CYP3A4 substrates for possible dosage changes.istradefylline will raise the stage or effect of diazepam by affecting